Ipamorelin
Selective GH secretagogue with minimal cortisol and prolactin side effects.
200 mcg twice daily
Key Benefits
stimulates GH without raising cortisol or prolactin
combines powerfully with CJC-1295 for amplified GH pulses
preclinical data shows improvements in bone mineral density
no appetite stimulation or cortisol spike unlike other GHRPs
Recommended Injection Sites
Optimal injection locations for Ipamorelin based on its route (Subcutaneous injection) and pharmacokinetic profile.
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Preferred for GH secretagogues.
Good alternative.
Rotate sites nightly.
- IV administration
- Intramuscular injection
Active Signaling Pathway
Recommended Stacks
Ipamorelin is a key compound in these curated research stacks. Pair it with synergistic peptides for enhanced outcomes.
GH Pulse Amplifier
The gold-standard two-signal GH stack — GHRH + GHRP for maximum physiological GH output.
How long will one vial last?
Based on standard research protocols, here's exactly what to expect from a single 5mg vial — and when to plan your next order.
Actual duration may vary based on your specific protocol. Always consult your research guidelines for precise dosing schedules.
Scientific Background
Mechanism of Action
Ipamorelin binds the ghrelin receptor (GHS-R1a) in the pituitary and hypothalamus, stimulating GH release via a cAMP-independent pathway. Its selectivity for GH over ACTH/cortisol is due to its pentapeptide structure, which avoids off-target receptor activation seen with other GHRPs.
Clinical Context
Ipamorelin is frequently combined with GHRH analogs (CJC-1295, Sermorelin) to produce synergistic GH pulses. The combination mimics the natural two-signal GH release mechanism more closely than either peptide alone.
Research Highlights
- Shown to increase GH pulse amplitude by 10–20× without elevating cortisol or prolactin
- Demonstrated synergistic GH release when combined with CJC-1295 or Sermorelin
- Preclinical data shows improvements in bone mineral density and lean mass
- Excellent safety profile in multiple animal studies — no desensitization at standard doses
Storage & Reconstitution
Store at -20°C. Reconstitute with 2 mL bacteriostatic water → 2.5 mg/mL. Stable 30 days at 2–8°C.
Best combined with CJC-1295 for synergistic GH release. Typical cycle: 8–12 weeks.