SWISSNOVALABS
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Kisspeptin-10 research vial
SwissNova Labs
Kisspeptin-10 · 5mg
≥99% Purity · COA Included
Hormonal

Kisspeptin-10

Purity: 99%+
Size: 5mg
Grade: Research
Form: Lyophilized
✦
SwissNova Labs · Research Grade
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HormonalNEW!

Kisspeptin-10

Hypothalamic neuropeptide regulating GnRH and reproductive hormone axis.

GnRH stimulation — directly activates hypothalamic GnRH neurons for hormonal cascadeLH/FSH release — drives pituitary gonadotropin secretion for testosterone and fertility supportHPG axis regulation — master regulator of reproductive endocrine functionHormonal research — used in clinical studies for hypogonadism and fertility
Strength5mg
$54.00
5mg · Research use only
Request COAResearch PDF
Compound Specifications
Purity99%+
Molecular Weight1302.5 Da
Vial Size5mg
SequenceYNWNSFGLRF-NH2
Vial Supply
Duration~10 weeks supply
Week 1Week 10
Why Researchers Choose This Compound

Key Benefits

01
GnRH stimulation

directly activates hypothalamic GnRH neurons for hormonal cascade

02
LH/FSH release

drives pituitary gonadotropin secretion for testosterone and fertility support

03
HPG axis regulation

master regulator of reproductive endocrine function

04
Hormonal research

used in clinical studies for hypogonadism and fertility

Mechanism of Action

Active Signaling Pathway

BioHuman Research Dossier
PreclinicalResearch use only — not for human consumption

Investigated Pathways

Kiss1R (GPR54)GnRH PulseHPG AxisReproductive Research

Proposed Mechanism

Kisspeptin-10 binds the KISS1R (GPR54) receptor on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release. This activates the pituitary to secrete LH and FSH, which in turn stimulate gonadal steroidogenesis. It is the master regulator of the reproductive endocrine axis.

Research Highlights

  • Single IV dose shown to increase LH by 10–20× in healthy volunteers
  • Used in clinical research to diagnose and treat hypogonadotropic hypogonadism
  • Demonstrated role in puberty onset and fertility regulation
  • Research shows potential for testosterone optimization in males with secondary hypogonadism
PreclinicalEvidence Strength

Evidence is primarily from in vitro cell studies and animal models. Human data is limited or absent.

Research FocusBrain & CNS
Brain & CNS body system research map
Brain & CNS

For laboratory research only

All Research Systems →

For research use only — not for human consumption. No treatment claims.

Full Research Hub →
Synergistic Protocols

Recommended Stacks

Kisspeptin-10 is a key compound in these curated research stacks. Pair it with synergistic peptides for enhanced outcomes.

Fitness & Performance

Hormonal Vitality Stack

HPG axis activation + melanocortin optimization — the complete vitality and libido research protocol.

Sexual Health
Kisspeptin-10 — Primary — HPG axis activation
Activates GnRH neurons to drive LH and FSH release, stimulating natural testosterone production. The master upstream regulator of the reproductive endocrine axis.
8–12 weeksAdvanced2 compounds
View Full Stack →
Supply Calculator

How long will one vial last?

Based on standard research protocols, here's exactly what to expect from a single 5mg vial — and when to plan your next order.

One vial lasts
10
weeks
Approximately 2 months of supply at standard protocol volumes.
Reorder around week 9 to avoid running out
Your supply timeline5mg vial
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Vial supply estimate is based on standard research protocol volumes. Actual duration will vary based on your specific protocol design.

Research Literature

Scientific Background

Mechanism of Action

Kisspeptin-10 binds the KISS1R (GPR54) receptor on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release. This activates the pituitary to secrete LH and FSH, which in turn stimulate gonadal steroidogenesis. It is the master regulator of the reproductive endocrine axis.

Clinical Context

Kisspeptin is now recognized as the primary upstream regulator of the HPG axis. Clinical trials are ongoing for its use in fertility treatment and hormonal disorders.

Research Highlights

  • Single IV dose shown to increase LH by 10–20× in healthy volunteers
  • Used in clinical research to diagnose and treat hypogonadotropic hypogonadism
  • Demonstrated role in puberty onset and fertility regulation
  • Research shows potential for testosterone optimization in males with secondary hypogonadism

Storage & Reconstitution

Peer-Reviewed Research

Key Studies

2005Journal of Clinical Endocrinology & Metabolism

Kisspeptin-10 stimulates LH secretion in healthy men

Dhillo WS et al.

Single IV dose of kisspeptin-10 increased LH by 10–20× in healthy male volunteers, confirming potent HPG axis activation.

PubMed →
2011Journal of Clinical Endocrinology & Metabolism

Kisspeptin-54 stimulates gonadotropin release in hypogonadal men

Jayasena CN et al.

Kisspeptin administration restored LH pulsatility and testosterone levels in men with hypogonadotropic hypogonadism.

PubMed →
2014Clinical Endocrinology

Kisspeptin and fertility

Jayasena CN et al.

Kisspeptin-10 pulsatile administration successfully triggered ovulation in women with hypothalamic amenorrhea.

PubMed →
Absorption & Distribution

Pharmacokinetics

PK Parameters
Bioavailability~70% SubQ
Peak Plasma30–60 min
Half-life~28 min; short half-life requires pulsatile dosing to mimic physiological GnRH release
ClearanceProteolytic degradation; renal clearance
Volume of Distribution~0.3 L/kg
What this means

Bioavailability indicates how much of the compound reaches systemic circulation. Peak plasma is when blood levels are highest. Half-life determines dosing frequency — compounds with short half-lives require more frequent dosing to maintain therapeutic levels.

The volume of distribution reflects how widely the compound distributes into tissues. A higher Vd means the compound concentrates in tissues rather than staying in plasma.

Molecular Targets

Receptor Binding Profile

KISS1R (GPR54)Full agonist

Triggers pulsatile GnRH release from hypothalamic neurons

Hypothalamic GnRH neuronsStimulation

Activates LH and FSH secretion from pituitary

LH/FSH axisDownstream activation

Stimulates gonadal steroidogenesis — testosterone in males, estrogen in females

Safety Profile

Side Effects & Adverse Events

Common
  • Injection site reactions
  • Mild flushing
Uncommon
  • Headache
  • Nausea
Serious
  • None documented at research doses
NOTE:Endogenous neuropeptide; well-tolerated in human clinical trials. No serious adverse events reported across multiple Phase 1/2 studies.
Research Safety

Contraindications & Interactions

Absolute Contraindications
Hormone-sensitive cancers (prostate cancer, breast cancer — stimulates testosterone/estrogen)
Relative Contraindications
Existing hormonal therapy (may interfere)Active fertility treatment (coordinate with specialist)
Drug Interactions
GnRH analogs (competitive or additive)Testosterone therapy (may interfere with endogenous axis)Estrogen therapy
NOTE:Stimulates endogenous testosterone/estrogen production. May interfere with exogenous hormone replacement protocols.
Stack Protocols

Synergistic Compounds

Sermorelin

Kisspeptin optimizes the HPG axis (testosterone/estrogen) while sermorelin optimizes the GH/IGF-1 axis — comprehensive hormonal optimization.

Kisspeptin-10 50 mcg SubQ AM + Sermorelin 300 mcg SubQ pre-sleep.

View Compound →
Sourcing & Testing

Transparent Global Sourcing

🇨🇳

Manufactured

Sourced through our manufacturing partner in China

🧪

Independent Testing

Analytical reports available from Janoshik Analytical

🔍

Batch Verification

Batch-specific COAs with online verification via janoshik.com

🇺🇸

US Fulfillment

Orders fulfilled from the United States

Testing documentation varies by product and batch. Customers may review available reports and verification information before ordering. COA task numbers and verification keys can be confirmed directly at janoshik.com/verification. For research use only — not for human consumption.
RESEARCH USE ONLY:All products are sold strictly for in vitro research and laboratory use. Not intended for human consumption, clinical use, diagnosis, treatment, or prevention of any disease or condition. By purchasing, you confirm you are a qualified researcher and will use these compounds in accordance with all applicable laws and regulations.