Semax
ACTH-derived nootropic for cognitive enhancement and neuroprotection.
300 mcg twice daily
Key Benefits
2–4× increase in brain-derived neurotrophic factor
improves memory, attention, and processing speed
protects against ischemic and neurodegenerative damage
enhances key neurotransmitter systems
Recommended Injection Sites
Optimal injection locations for Semax based on its route (Intranasal (preferred) or subcutaneous injection) and pharmacokinetic profile.
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Preferred for CNS delivery.
SubQ alternative.
Rotate SubQ sites if using injectable route.
- IV administration
Active Signaling Pathway
Recommended Stacks
Semax is a key compound in these curated research stacks. Pair it with synergistic peptides for enhanced outcomes.
Nootropic Clarity & Focus
Anxiety-free cognitive enhancement — BDNF upregulation, focus, and neuroprotection.
How long will one vial last?
Based on standard research protocols, here's exactly what to expect from a single 5mg vial — and when to plan your next order.
Actual duration may vary based on your specific protocol. Always consult your research guidelines for precise dosing schedules.
Scientific Background
Mechanism of Action
Semax activates melanocortin receptors and upregulates BDNF, NGF, and VEGF expression in the brain. It enhances dopaminergic and serotonergic neurotransmission, improves cerebral blood flow, and activates neuroprotective gene expression programs.
Clinical Context
Semax has over 20 years of clinical use in Russia and Ukraine. Its BDNF-upregulating mechanism makes it particularly relevant for neuroplasticity and cognitive enhancement research.
Research Highlights
- Approved in Russia for stroke, TBI, and cognitive impairment treatment
- Shown to increase BDNF by 2–4× in hippocampal tissue
- Demonstrated improvements in attention, memory, and processing speed in clinical trials
- Neuroprotective in models of ischemia, Parkinson's, and Alzheimer's disease
Storage & Reconstitution
Store at -20°C. Reconstitute with sterile saline for intranasal use. Stable 2 weeks at 2–8°C after reconstitution.
Intranasal route provides direct CNS delivery. Typical cycle: 4–8 weeks.