Epithalon
Telomerase-activating tetrapeptide for cellular longevity and anti-aging.
Key Benefits
elongates telomeres in somatic cells for cellular longevity
13–24% lifespan increase in multiple animal models
restores pineal gland function and circadian rhythm
resets aging-associated gene expression patterns
Active Signaling Pathway
Investigated Pathways
Proposed Mechanism
Epithalon activates telomerase (hTERT) expression, enabling elongation of telomeres in somatic cells. It also regulates the hypothalamic-pituitary axis, normalizes melatonin secretion, and modulates gene expression patterns associated with aging via epigenetic mechanisms.
Research Highlights
- Shown to elongate telomeres in human somatic cells in vitro
- Extended lifespan by 13–24% in multiple animal studies (mice, fruit flies)
- Demonstrated restoration of melatonin secretion patterns in aging subjects
- 30+ years of research by the St. Petersburg Institute of Bioregulation and Gerontology
Research is at an early stage. Findings are preliminary and have not been replicated in controlled human studies.
For laboratory research only
All Research Systems →Human Body
Research begins at the whole-organism level — studying systemic metabolic markers, energy expenditure, and physiological response to peptide intervention.
For laboratory research and educational purposes only.
Human Body
Research begins at the whole-organism level — studying systemic metabolic markers, energy expenditure, and physiological response to peptide intervention.
For laboratory research and educational purposes only.
For research use only — not for human consumption. No treatment claims.
Full Research Hub →Recommended Stacks
Epithalon is a key compound in these curated research stacks. Pair it with synergistic peptides for enhanced outcomes.
Nootropic Clarity & Focus
Anxiety-free cognitive enhancement — BDNF upregulation, focus, and neuroprotection without stimulants.
Longevity & Anti-Aging
Target the three root mechanisms of biological aging — mitochondrial decline, NAD+ depletion, and telomere shortening.
How long will one vial last?
Based on standard research protocols, here's exactly what to expect from a single 10mg vial — and when to plan your next order.
Vial supply estimate is based on standard research protocol volumes. Actual duration will vary based on your specific protocol design.
Scientific Background
Mechanism of Action
Epithalon activates telomerase (hTERT) expression, enabling elongation of telomeres in somatic cells. It also regulates the hypothalamic-pituitary axis, normalizes melatonin secretion, and modulates gene expression patterns associated with aging via epigenetic mechanisms.
Clinical Context
Epithalon has one of the longest research histories of any longevity peptide, with studies dating to the 1980s. Clinical data from Russian gerontology institutes shows improvements in biomarkers of aging with periodic cycling protocols.
Research Highlights
- Shown to elongate telomeres in human somatic cells in vitro
- Extended lifespan by 13–24% in multiple animal studies (mice, fruit flies)
- Demonstrated restoration of melatonin secretion patterns in aging subjects
- 30+ years of research by the St. Petersburg Institute of Bioregulation and Gerontology
Storage & Reconstitution
Store at -20°C. Reconstitute with 2 mL bacteriostatic water → 5 mg/mL. Stable 4 weeks at 2–8°C.
Key Studies
Epithalon activates telomerase and elongates telomeres in human somatic cells
Khavinson VKh et al.
Epithalon activated telomerase (hTERT) and elongated telomeres in human somatic cells in vitro — first demonstration of a peptide with this activity.
PubMed →Epithalon extends lifespan and inhibits tumor development in mice
Anisimov VN et al.
Epithalon extended lifespan by 13–24% in multiple animal models and reduced spontaneous tumor incidence.
PubMed →Epithalon regulates pineal gland function and melatonin secretion
Khavinson VKh et al.
Epithalon restored melatonin secretion patterns in aging subjects, suggesting pineal gland regulatory effects.
PubMed →Pharmacokinetics
Bioavailability indicates how much of the compound reaches systemic circulation. Peak plasma is when blood levels are highest. Half-life determines dosing frequency — compounds with short half-lives require more frequent dosing to maintain therapeutic levels.
The volume of distribution reflects how widely the compound distributes into tissues. A higher Vd means the compound concentrates in tissues rather than staying in plasma.
Receptor Binding Profile
Enables telomere elongation in somatic cells — primary anti-aging mechanism
Restores melatonin secretion patterns in aging subjects
Cell cycle regulation and DNA repair support
Reduces oxidative damage via SOD and catalase upregulation
Side Effects & Adverse Events
- Mild injection site reactions
- Transient fatigue
- Vivid dreams (melatonin effect)
- Mild headache
- None documented in 30+ years of research
Contraindications & Interactions
Synergistic Compounds
Epithalon targets telomere length and pineal function while MOTS-c targets mitochondrial metabolism — complementary longevity mechanisms.
Epithalon 5 mg SubQ daily (10-day cycle) + MOTS-c 5 mg SubQ every other day.
View Compound →NAD+ activates sirtuins for longevity while Epithalon activates telomerase — complementary anti-aging pathways.
Epithalon 5 mg SubQ daily (10-day cycle) + NAD+ 250 mg SubQ 3× per week.
View Compound →Transparent Global Sourcing
Manufactured
Sourced through our manufacturing partner in China
Independent Testing
Analytical reports available from Janoshik Analytical
Batch Verification
Batch-specific COAs with online verification via janoshik.com
US Fulfillment
Orders fulfilled from the United States