TB-500 5mg
Thymosin Beta-4 — systemic tissue repair and anti-inflammatory peptide for accelerated recovery.
Key Benefits
travels via bloodstream to reach injury sites throughout the entire body
sequesters G-actin to promote cell movement and proliferation at repair sites
downregulates IL-6 and TNF-α to reduce chronic inflammation
stimulates VEGF pathway to improve blood supply to healing tissue
Active Signaling Pathway
Investigated Pathways
Proposed Mechanism
TB-500 works primarily by sequestering G-actin (monomeric actin), which promotes cell migration and proliferation at injury sites. It upregulates actin-binding proteins, stimulates angiogenesis via VEGF pathway activation, reduces inflammation by downregulating inflammatory cytokines (IL-6, TNF-α), and promotes differentiation of stem cells into repair-competent cells. Its systemic distribution via blood allows it to reach distant injury sites.
Research Highlights
- Demonstrated systemic tissue repair — distributes via bloodstream to reach distant injury sites
- Shown to reduce cardiac fibrosis and promote heart muscle repair in myocardial infarction models
- Anti-inflammatory effects documented — reduces IL-6 and TNF-α at injury sites
- Promotes hair follicle stem cell activation — studied for hair regrowth applications
Human observational or open-label study data exists. Controlled trial data may be limited. Not a treatment recommendation.
For research use only — not for human consumption. No treatment claims.
Full Research Hub →Recommended Stacks
TB-500 5mg is a key compound in these curated research stacks. Pair it with synergistic peptides for enhanced outcomes.
Wolverine Recovery Stack
The gold-standard dual-peptide repair protocol — BPC-157 + TB-500 for connective tissue, muscle, and systemic healing.
Lean Body Recomposition
Build lean muscle while burning fat simultaneously — the holy grail of body composition research.
How long will one vial last?
Based on standard research protocols, here's exactly what to expect from a single 5mg vial — and when to plan your next order.
Vial supply estimate is based on standard research protocol volumes. Actual duration will vary based on your specific protocol design.
Scientific Background
Mechanism of Action
TB-500 works primarily by sequestering G-actin (monomeric actin), which promotes cell migration and proliferation at injury sites. It upregulates actin-binding proteins, stimulates angiogenesis via VEGF pathway activation, reduces inflammation by downregulating inflammatory cytokines (IL-6, TNF-α), and promotes differentiation of stem cells into repair-competent cells. Its systemic distribution via blood allows it to reach distant injury sites.
Clinical Context
TB-500 is widely used in research protocols for musculoskeletal injuries, particularly when the injury is difficult to inject near (e.g., spine, deep tissue). Its systemic distribution makes it complementary to BPC-157, which has more localized effects. The combination of BPC-157 + TB-500 (the Wolverine Stack) is one of the most popular recovery protocols.
Research Highlights
- Demonstrated systemic tissue repair — distributes via bloodstream to reach distant injury sites
- Shown to reduce cardiac fibrosis and promote heart muscle repair in myocardial infarction models
- Anti-inflammatory effects documented — reduces IL-6 and TNF-α at injury sites
- Promotes hair follicle stem cell activation — studied for hair regrowth applications
Storage & Reconstitution
Key Studies
Thymosin beta4 promotes cardiac repair after myocardial infarction
Goldstein AL et al.
TB-500 demonstrated systemic tissue repair via blood-borne distribution, reducing cardiac fibrosis and promoting heart muscle repair.
PubMed →Thymosin beta4 promotes corneal wound healing
Sosne G et al.
TB-500 accelerated corneal wound healing via G-actin sequestration and anti-inflammatory mechanisms.
PubMed →Thymosin beta4 for cardiac regeneration
Ho EN et al.
TB-500 promoted cardiac progenitor cell activation and regeneration in myocardial infarction models.
PubMed →Pharmacokinetics
Bioavailability indicates how much of the compound reaches systemic circulation. Peak plasma is when blood levels are highest. Half-life determines dosing frequency — compounds with short half-lives require more frequent dosing to maintain therapeutic levels.
The volume of distribution reflects how widely the compound distributes into tissues. A higher Vd means the compound concentrates in tissues rather than staying in plasma.
Receptor Binding Profile
Promotes cytoskeletal remodeling and cell migration at injury sites
Enhances cell migration and tissue repair signaling
Angiogenesis and improved blood supply to healing tissue
Anti-inflammatory — reduces IL-6 and TNF-α at injury sites
Side Effects & Adverse Events
- Injection site discomfort
- Temporary fatigue
- Headache
- Flushing
- None documented in research
Contraindications & Interactions
Synergistic Compounds
The classic Wolverine Stack — BPC-157 targets local angiogenesis and growth factor signaling while TB-500 provides systemic cell migration and anti-inflammatory effects.
TB-500 2 mg + BPC-157 250–500 mcg, both SubQ, daily or every other day for 4–8 weeks.
View Compound →Transparent Global Sourcing
Manufactured
Sourced through our manufacturing partner in China
Independent Testing
Analytical reports available from Janoshik Analytical
Batch Verification
Batch-specific COAs with online verification via janoshik.com
US Fulfillment
Orders fulfilled from the United States