KPV
Anti-inflammatory tripeptide derived from alpha-MSH for gut and systemic healing.
1 mg/day
Key Benefits
blocks the master inflammatory signaling pathway at the cellular level
shown to reduce intestinal inflammation in IBD research models
accelerates tissue repair and reduces inflammatory scarring
active via oral, topical, and injectable administration
Recommended Injection Sites
Optimal injection locations for KPV based on its route (Subcutaneous injection or oral) and pharmacokinetic profile.
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Tap a zone to inject
Preferred SubQ site.
Good alternative.
Rotate sites to prevent lipodystrophy.
- IV administration
Active Signaling Pathway
Recommended Stacks
KPV is a key compound in these curated research stacks. Pair it with synergistic peptides for enhanced outcomes.
Wolverine Rapid Recovery
Aggressive multi-peptide healing stack for connective tissue, muscle, and systemic repair.
How long will one vial last?
Based on standard research protocols, here's exactly what to expect from a single 5mg vial — and when to plan your next order.
Actual duration may vary based on your specific protocol. Always consult your research guidelines for precise dosing schedules.
Scientific Background
Mechanism of Action
KPV exerts anti-inflammatory effects by directly entering cells and inhibiting NF-κB activation — the master regulator of inflammatory gene expression. It also acts on melanocortin receptors (MC1R, MC3R) to suppress pro-inflammatory cytokine production (IL-1β, TNF-α, IL-6).
Clinical Context
KPV is particularly relevant for gut inflammation research. Its ability to be absorbed orally and act directly on intestinal epithelial cells makes it unique among anti-inflammatory peptides.
Research Highlights
- Shown to reduce colitis severity by 60–70% in murine IBD models
- Demonstrated direct cellular uptake — can act intracellularly without receptor binding
- Effective via oral, topical, and injectable routes in preclinical studies
- Shown to accelerate wound healing and reduce scar formation
Storage & Reconstitution
Store at -20°C. Reconstitute with 1 mL bacteriostatic water → 5 mg/mL. Stable 4 weeks at 2–8°C.
Oral bioavailability demonstrated in preclinical studies. Typical cycle: 4–8 weeks.