Tesamorelin 10mg
High-dose FDA-approved GHRH analog for visceral fat reduction and body composition optimization.
2 mg/day (standard protocol)
Key Benefits
FDA-approved mechanism showing 15–18% VAT reduction in clinical trials
stimulates natural pulsatile GH release without suppressing the hypothalamic-pituitary axis
reduces visceral fat while preserving lean muscle mass
emerging research shows improvements in executive function and memory via IGF-1 signaling
Recommended Injection Sites
Optimal injection locations for Tesamorelin 10mg based on its route (Subcutaneous injection) and pharmacokinetic profile.
Tap a glowing zone on the body map to highlight the matching site card — or tap a card to activate the zone.
Tap a zone to inject
Standard injection site for Tesamorelin. Rotate quadrants.
Good alternative. Slightly slower absorption.
Use shorter needle (5/16"). Requires assistance.
Rotate injection sites to prevent lipodystrophy. Maintain ≥1 inch between injection points.
- IV administration
- Intramuscular injection
- Areas with active lipodystrophy
Active Signaling Pathway
How long will one vial last?
Based on standard research protocols, here's exactly what to expect from a single 10mg vial — and when to plan your next order.
Actual duration may vary based on your specific protocol. Always consult your research guidelines for precise dosing schedules.
Scientific Background
Mechanism of Action
Tesamorelin is a stabilized analog of endogenous GHRH with a trans-3-hexenoic acid group attached to the N-terminus, which protects it from dipeptidyl peptidase IV (DPP-IV) degradation and extends its half-life to 26–38 minutes. It binds to GHRH receptors on pituitary somatotrophs, triggering cAMP-mediated GH synthesis and pulsatile release. The resulting GH elevation stimulates hepatic IGF-1 production, which mediates the lipolytic effects on visceral fat.
Clinical Context
Tesamorelin has the strongest clinical evidence base of any GHRH analog, with multiple Phase III trials and FDA approval. Its visceral fat reduction effects are well-documented, and emerging research suggests cognitive benefits via IGF-1 signaling in the brain. The 10mg vial allows for extended protocols without frequent reordering.
Research Highlights
- FDA-approved (2010) for HIV-associated lipodystrophy — one of the most rigorously studied GHRH analogs
- Phase III trials showed 15–18% reduction in visceral adipose tissue (VAT) over 26 weeks
- Demonstrated improvements in cognitive function (executive function, memory) in adults with mild cognitive impairment
- Unlike direct GH, Tesamorelin preserves the natural GH feedback loop via somatostatin — no axis suppression
Storage & Reconstitution
Standard protocol: 2 mg/day SubQ. Reconstitute immediately before use — inject within 3 hours. 5/2 protocol (5 days on, 2 days off) also used.